Application Notes

In the field of medium-scale recombinant protein and antibody production in suspension CHO cells, transient transfection using FectoCHO® Expression System can quickly and efficiently provide high mAbs titers. When combined with MabXpure™ purification technologies, it allows for the compensation of expensive affinity resin use after a clarification step.

Combining multimodal depletion mechanisms, MabXpure enables Plug & Play cost effective polishing strategies for the removal of impurities such as host cell DNA and proteins, aggregates, viruses and endotoxins. The use of MabXpure allows for the removal of co-eluted HCP for formulation purpose.

The combining of MabXpure with other depletion agents during clarification/alluvial filtration allows for unrivaled depletion of impurities making “MabXpure Plus” a mAb purification flowthrough platform gamechanger. Following up with a protein A step supports reaching drug substance purity.

DAISEP MabXpure™, a single-use multimodal (SEC-AEX) flowthrough (FT) technology application offering a high-performance solution for the depletion and reduction of Host Cell Proteins (HCPs) and DNA following clarification / harvest, during purification, polishing and sample preparation of MAbs and large molecules.

DAISEP MabXpure™, a disposable bead-based multimodal (SEC-AEX) flowthrough technology offering high depletion performances for Host Cell Proteins and DNA during clarification/harvest stages and sample preparation steps for mAb product solutions.