MabXpure is the world’s first single-use, disposable resin for bioprocess purification dedicated to the mAb industry. This DAISEP technology-based depletion media features a high selectivity for product and process related contaminant such as host-cell proteins (HCPs), DNA, and other impurities while maintaining high mAB recovery.
MabXpure combines an innovative modified silica with multimodal size exclusion anion exchange chemistries for improved scavenging properties in flowthrough mode under a wide range of conditions including pH, conductivity, buffers, mix ratio, and contact time.
MabXpure can be mixed directly with your cell culture sample and filtered off during harvest or clarification steps (midstream operations), or in dynamic conditions using ready to use formats for polishing step in the purification platform (downstream operations).
MabXpure’s single-use design will streamline process development or ease sample preparation steps. MabXpure protects the platform performance when challenged by non-ideal cell culture contaminant profiles.
SPECIFICATION
| Base Matrix | Modified Silica |
|---|---|
| Type | Multimodal SEC-AEX |
| Particle Size (D50V) | 35 µm |
| Recommended Contact Time | 1-120 min |
| Storage Solution / Temperature | 20% Ethanol / 4-30°C |
| pH Stability, CIP (short term) | 1-13 |
| pH Stability, working range | 2-12 |
MABXPURE
MabXpure bulk depletion media is available in 50 mL and 500 mL. MabXpure is supplied in 20% Ethanol.
MABXPURE SPECIFICATION
| MabXpure 50 mL | MabXpure 500 mL | |
|---|---|---|
| Base Matrix | Modified Silica | Modified Silica |
| Type | Multimodal SEC-AEX | Multimodal SEC-AEX |
| Particle Size (D50v) | 35 µm | 35 µm |
| Storage / Temperature | 20% Ethanol / 4-30°C | 20% Ethanol / 4-30°C |
| Slurry | 50/50 v/v | 50/50 v/v |
| Shelf-life (estimated) | 2 years | 2 years |
MABXPURE ORDERING INFORMATION
| Product | Quantities | Order Code |
|---|---|---|
| MabXpure 50 mL | 50 mL | DMXBK0050 |
| MabXpure 500 mL | 500 mL | DMXBK0500 |
For larger quantities, please contact us at cte@daicelbioseparations.com
MABXPURE FT
MabXpure FT was developed as pre-filled 1 mL and 5 mL ready to use format for tests in dynamic conditions. MabXpure FT is compatible with common chromatography equipment, low pressure pumps and syringes. MabXpure FT formats can be tested at different loading conditions including pH, conductivity, buffer, residence time.
MABXPURE FT SPECIFICATION
| MabXpure FT 1 mL | MabXpure FT 5 mL | |
|---|---|---|
| Bed Dimension | 7 mm ID x 25 mm H | 16 mm ID x 25 mm H |
| Recommended Flow Rate | 0.2-1 mL/min | 1-5 mL/min |
| Max. Operating Pressure | 0.5MPa (72psi) | 0.5MPa (72psi) |
| Column Construction | Polypropylene | Polypropylene |
| Inlet Port | 10-32 (1/16”) Female | 10-32 (1/16”) Female |
| Outlet Port | 10-32 (1/16”) Male | 10-32 (1/16”) Male |
| Storage/Temperature | 20% Ethanol / 4-30°C | 20% Ethanol / 4-30°C |
MABXPURE FT ORDERING INFORMATION
| Product | Quantities | Order Code |
|---|---|---|
| MabXpure FT 1 mL | 5*1 mL | DMXFT0001 |
| MabXpure FT 5 mL | 5*5 mL | DMXFT0005 |
For larger volumes, please contact us at cte@daicelbioseparations.com
MABXPURE KIT
The MabXpure Kit provides all 3 formats to evaluate the performance of MabXpure under flowthrough and batch conditions.
MABXPURE KIT SPECIFICATION
| Product | Units | |
|---|---|---|
| MabXpure | MabXpure 50 mL | 1 Unit |
| MabXpure FT | MabXpure FT 1 mL | 4 Units |
| MabXpure FT | MabXpure FT 5 mL | 1 Unit |
| DAISEP Spin | DAISEP Spin XS | 2 Units |
| DAISEP Spin | DAISEP Spin XL | 3 Units |
DAISEP SPIN
DAISEP Spin columns are designed for small scale mAb purifications, allowing you to mix your filtered or unclarified cell culture sample with depletion media. DAISEP Spin XS and DAISEP Spin XL columns incorporate a SelfSealTM membrane technology which retain the depletion media and sample in the batch incubation chamber. This enables testing various depletion media:sample mix ratios, and contact times. When column is spun at 750 x g in a benchtop centrifuge, the pores of the membrane dilate and the filtered sample is collected in the bottom of the centrifuge tube.
DAISEP SPIN SPECIFICATION
| DAISEP Spin XS | DAISEP Spin XL | |
|---|---|---|
| Spin Column Construction | Polypropylene | Polypropylene, TPE |
| Mean sinter pore size | 0.1-0.2 µm | 0.1-0.2 µm |
| Sinter Construction | UHDPE | UHDPE |
| Max G Force | 2,500 | 1,500 |
| Reservoir Capacity (max) | 0.6 mL | 22 mL |
DAISEP SPIN ORDERING INFORMATION
| Product | Quantities | Order Code |
|---|---|---|
| DAISEP Spin XS | 40 units | DSPXS0040 |
| DAISEP Spin XL | 8 units | DSPXL0008 |
For larger quantities, please contact us at cte@daicelbioseparations.com
REQUEST A QUOTE
To place an order, please contact us via email using the following address: cte@daicelbioseparations.com
For more information, you can also contact your local support via telephone Tel: +33 (0) 3.88.79.52.00
